What do we do?
The Bioinformatics, Data Analytics and Predictive Modeling Core both develops new bioinformatics and systems biology methods and tools and supports Center staff in providing bioinformatic and statistical services. Working with the Center's research collaborators, the Core stores, retrieves and analyzes the vast amount of data from the Center’s experiments. The availability of a responsive and dedicated bioinformatics and statistical support team enables the Core to provide rapid data management and processing support, facilitating the timely and accurate analysis and interpretation of the results. In addition, we develop user-friendly and open-access tools that are made available to the entire research community, including NeuroPred (a prohormone processing and peptide predictor), PepShop (one stop integration of peptide sequence and mass spectra information), and neuroProsight (a top-down proteomics toolset). These resources are complemented with an array of transcriptomics and proteomics workflows for a range of experimental designs developed and tested by the Core. Combining these efforts with the world-class computational and informatics capabilities available at the both the University of Illinois and Northwestern University, the Bioinformatics, Data Analytics and Predictive Modeling Core provides a vast range of technical support services to the neuroscience research community.
Representative recent publications
Influence of Maternal Immune Activation and Stressors on the Hippocampal Metabolome, B.R. Southey, R.W. Johnson, S.L. Rodriguez-Zas, Metabolites 13, 2023, 881. DOI:10.3390/metabo13080881
Genes Participating in the Ensheathment of Neurons Are Affected by Postnatal Stress and Maternal Immune Activation in the Pituitary Gland, S. Alsegehy, B.R. Southey, L. Rund, R.W. Johnson, S.L. Rodriguez-Zas, Genes (Basel) 14, 2023, 1007. DOI:10.3390/genes14051007
Prefrontal Cortex Response to Prenatal Insult and Postnatal Opioid Exposure, H.E. Rymut, L.A. Rund, B.R. Southey, R.W. Johnson, J.V. Sweedler, S.L. Rodriguez-Zas, Genes (Basel) 13, 2022, 1371. DOI:10.3390/genes13081371
Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia, P. Zhang, O.C. Perez, B.R. Southey, J.V. Sweedler, A.A. Pradhan, S.L. Rodriguez-Zas, Genes (Basel) 12, 2021, 1570. DOI:10.3390/genes12101570
Enhanced Understanding of Molecular Interactions and Function Underlying Pain Processes Through Networks of Transcript Isoforms, Genes, and Gene Families, P. Zhang, B.R. Southey, J.V. Sweedler, A. Pradhan, S.L. Rodriguez-Zas, Adv. Appl. Bioinform. Chem. 14, 2021, 49–69. DOI:10.2147/AABC.S284986