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Isotopic Resolution of Protein Complexes up to 466 kDa Using Individual Ion Mass Spectrometry

J.P. McGee, R.D. Melani, P.F.Yip, M.W. Senko, P.D. Compton, J.O. Kafader, N.L. Kelleher, Anal. Chem. 93, 2723–2727.

About the cover: Individual ion mass spectrometry (I2MS) enables isotopic resolution of large, noncovalent protein complexes (pyruvate kinase, β-galactosidase) on Orbitrap mass spectrometers.